Current Issue : April - June Volume : 2018 Issue Number : 2 Articles : 5 Articles
Alginate and Ã?²-cyclodextrin were used to produce easily dosable and spray-dried microsystems of a dried blood orange extract with\nantidysmetabolic properties, obtained from a by-product fluid extract. The spray-dried applied conditions were able to obtain a\nconcentrate dried extract without the loss of AOA and with TPC and TMA values of 35ââ?¬â??40% higher than that of the starting\nmaterial. They were also effective in producing microparticles with 80ââ?¬â??100% of encapsulation efficiency. The 2% sodium\nalginate was capable of improving the extract shelf life, while the beta-cyclodextrin (1 : 1 molar ratio with dried extract)\nprolonged the extract antioxidant efficiency by 6 hours. The good inhibition effect of the dried extract on the AGE formation\nand the MMP-2 and MMP-9 activity is presumably due to a synergic effect exerted by both anthocyanin and bioflavonoid\nextract compounds and was improved by the use of alginate and cyclodextrin....
The susceptibility of guided bone regeneration (GBR) material to infection by pathogens\nat wound sites during bone healing has often been overlooked. The objective of this study was the\nsynthesis and characterization of a potential material for antibacterial GBR application. In the current\nstudy, the mechanical strength and biocompatibility of a composite restoration materialââ?¬â?made\nof oxidized hyaluronic acid (HA)/type I collagen hydrogel integrated with tricalcium phosphate\n(Ã?²-TCP) using a natural crosslinking agent, oligomeric proanthocyanidins (OPCs)ââ?¬â?were evaluated.\nThe suitability of the material as a carrier matrix for antibacterial applications was evaluated by\nfollowing the drug-release profile of tetracycline loaded within the composite. Results indicated that\nthis composite material had a high swelling ratio of 420% and mechanical strength of 25 kPa while\nremaining at more than 60% of the weight after 30 days of an in vitro degradation test with good\nbiocompatibility in promoting the proliferation of MG-63 cells. Drug release studies further showed\nthat 93% of the tetracycline was released after 5 days, which supports this GBR materialââ?¬â?¢s capability\nto release antibacterial drugs while keeping other required GBR material design functions....
During the regulatory requested process validation of pharmaceutical manufacturing\nprocesses, companies aim to identify, control, and continuously monitor process variation and its\nimpact on critical quality attributes (CQAs) of the final product. It is difficult to directly connect the\nimpact of single process parameters (PPs) to final product CQAs, especially in biopharmaceutical\nprocess development and production, where multiple unit operations are stacked together and\ninteract with each other. Therefore, we want to present the application of Monte Carlo (MC)\nsimulation using an integrated process model (IPM) that enables estimation of process capability\neven in early stages of process validation. Once the IPM is established, its capability in risk\nand criticality assessment is furthermore demonstrated. IPMs can be used to enable holistic\nproduction control strategies that take interactions of process parameters of multiple unit operations\ninto account. Moreover, IPMs can be trained with development data, refined with qualification\nruns, and maintained with routine manufacturing data which underlines the lifecycle concept.\nThese applications will be shown by means of a process characterization study recently conducted at\na world-leading contract manufacturing organization (CMO). The new IPM methodology therefore\nallows anticipation of out of specification (OOS) events, identify critical process parameters, and take\nrisk-based decisions on counteractions that increase process robustness and decrease the likelihood\nof OOS events....
Microencapsulations of Lactobacillus acidophilus in xanthan-chitosan (XC) and\nxanthan-chitosan-xanthan (XCX) polyelectrolyte complex (PEC) gels were prepared in this study.\nThe process of encapsulation was optimized with the aid of response surface methodology (RSM).\nThe optimum condition was chitosan of 0.68%, xanthan of 0.76%, xanthan-L. acidophilus mixture\n(XLM)/chitosan of 1:2.56 corresponding to a high viable count (1.31 Ã?± 0.14) Ã?â?? 1010 CFUÃ?·gâË?â??1, and\nencapsulation yield 86 Ã?± 0.99%, respectively. Additionally, the application of a new encapsulation\nsystem (XC and XCX) in yoghurt achieved great success in bacterial survival during the storage of\n21 d at 4 ââ??¦C and 25 ââ??¦C, respectively. Specially, pH and acidity in yogurt were significantly influenced\nby the new encapsulation system in comparison to free suspension during 21 d storage. Our study\nprovided a potential encapsulation system for probiotic application in dairy product which paving a\nnew way for functional food development...
Titanium and its alloys have been widely used in the manufacture of endosseous implants due to excellent biocompatibility, low\nelastic modulus, and good chemical stability. However, the titanium based metals are essentially bioinert materials. In order to\nimprove their bioactivity, biological coatings are usually applied. Recent studies found that, compared with hydroxyapatite coating,\ndicalcium phosphate anhydrous (DCPA, Monetite) coating maybe more bioactive due to higher solubility and release of Ca and P\nions. In this work, DCPA coating was prepared through a novel and simple method. Briefly, high concentration DCPA solution was\nsprayed onto superhydrophilic titanium and the specimens were dried fast in an air-circulating oven. After repeating the process\nover 100 times, a compact coating was fabricated. The microstructure, chemical composition, wettability, and in vitro bioactivity of\nthe coating were analyzed and evaluated. Results showed that the coating fully covered the substrate and consisted of a large number\nof uniformly sized DCPA granules that packed together closely. The coating showed good wettability and could keep the property\nfor a long time. After immersion in simulated body fluid for 2 weeks, a large amount of bone-like apatite with low crystallinity was\ninduced implying a good bioactivity....
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